ATTR cardiac amyloidosis (ATTR-CM) is a progressive and often underdiagnosed cause of heart failure, particularly in older adults and patients with unexplained left ventricular hypertrophy. Early and accurate diagnosis is essential, as disease-modifying therapies are now available and outcomes improve significantly when treatment begins before advanced cardiac damage occurs.

However, ATTR-CM frequently goes unrecognized because its symptoms overlap with more common cardiovascular conditions. A structured and systematic diagnostic approach is therefore critical.