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Amyloidosis Insights and Research in Africa

Explore the latest articles on amyloidosis awareness, research, diagnosis, and clinical education in Africa. Our blog shares expert insights, emerging scientific evidence, and initiatives aimed at improving early detection and patient care across the continent.

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What is Amyloidosis

What Is Amyloidosis? Types, Symptoms, Diagnosis and Treatment

Amyloidosis is a group of diseases caused by abnormal amyloid protein deposits in tissues and organs. Learn about AL, ATTR and AA amyloidosis, their symptoms, diagnosis and treatment.

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Amyloidosis Symptoms

Cardiac Amyloidosis: Red Flags, Symptoms, Diagnosis and When to Suspect It

Cardiac amyloidosis is an important and often under-recognized cause of heart failure and increased ventricular wall thickness. Learn the key cardiac and extracardiac red flags, differences between ATTR-CM and AL-CM, and the modern diagnostic pathway using laboratory testing, echocardiography, CMR and bone scintigraphy.

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Amyloidosis Types

Wild-Type ATTR Amyloidosis: Symptoms, Diagnosis & Treatment

Wild-type ATTR amyloidosis is a progressive disease caused by misfolding of normal transthyretin. Learn about cardiac and musculoskeletal red flags, diagnosis, treatment and monitoring.

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Amyloidosis Types

Hereditary ATTR Amyloidosis: Genetics, Symptoms, Diagnosis & Treatment

Hereditary ATTR amyloidosis is an inherited disease caused by pathogenic TTR variants. Learn about inheritance, symptoms, cardiac and neurologic involvement, genetic testing, diagnosis, family screening and treatment.

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Amyloidosis Types

AA Amyloidosis: Causes, Symptoms, Diagnosis and Treatment

AA amyloidosis is a systemic disease caused by persistent inflammation and prolonged serum amyloid A production. It most often affects the kidneys, leading to proteinuria, nephrotic syndrome, and progressive kidney dysfunction. This article explains the causes, clinical features, diagnosis, amyloid typing, and treatment of AA amyloidosis.

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Amyloidosis Types

AL Amyloidosis: Causes, Symptoms, Diagnosis and Treatment

AL amyloidosis is caused by abnormal immunoglobulin light chains produced by a clonal plasma-cell disorder. Learn about key symptoms, cardiac and renal red flags, diagnostic testing, biopsy, amyloid typing and treatment.

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Amyloidosis Types

ATTR Amyloidosis: Wild-Type vs Hereditary ATTR, Symptoms, Diagnosis & Treatment

ATTR amyloidosis is caused by the accumulation of misfolded transthyretin protein in tissues. Learn the differences between wild-type and hereditary ATTR, important cardiac and neurological red flags, how ATTR is diagnosed, the role of genetic testing, and current treatment approaches.

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Amyloidosis Types

ATTR vs AL Amyloidosis: Key Differences in Causes, Red Flags, Diagnosis and Treatment.

ATTR and AL amyloidosis can both affect the heart but arise from different precursor proteins and require different treatment. Learn the key differences in causes, red flags, diagnosis, testing and management.

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Amyloidosis Symptoms

Cardiac Amyloidosis: Red Flags, Symptoms, Diagnosis and When to Suspect It

Cardiac amyloidosis is an important and often under-recognized cause of heart failure and increased ventricular wall thickness. Learn the key cardiac and extracardiac red flags, differences between ATTR-CM and AL-CM, and the modern diagnostic pathway using laboratory testing, echocardiography, CMR and bone scintigraphy.

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Amyloidosis Diagnosis

Biopsy in Cardiac Amyloidosis: Tissue Diagnosis, Congo Red Staining and Amyloid Typing

Biopsy remains important when cardiac amyloidosis cannot be diagnosed confidently by non-invasive testing. Learn when tissue sampling is needed, how Congo red confirms amyloid, and why accurate amyloid typing is essential.

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Amyloidosis Diagnosis

Genetic Testing in Transthyretin Cardiac Amyloidosis: ATTRv, ATTRwt and Family Screening

Genetic testing helps distinguish hereditary ATTR amyloidosis from wild-type disease. Learn when to test, how TTR variants are interpreted, and what results mean for patients and their families.

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Amyloidosis Diagnosis

Monoclonal Protein Testing in Cardiac Amyloidosis: Free Light Chains, Immunofixation and AL Screening

Monoclonal protein testing is a critical step in the evaluation of suspected cardiac amyloidosis. Learn how serum free light chains and serum and urine immunofixation help identify possible AL amyloidosis and guide the diagnostic pathway toward an accurate amyloid subtype diagnosis.

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Amyloidosis Diagnosis

Cardiac Magnetic Resonance Imaging in Cardiac Amyloidosis: LGE, T1 Mapping and ECV

Cardiac magnetic resonance imaging provides detailed tissue characterization in cardiac amyloidosis. Learn how late gadolinium enhancement, native T1 mapping, extracellular volume and abnormal myocardial nulling support diagnosis and assessment.

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Amyloidosis Diagnosis

Bone Scintigraphy Imaging of Cardiac Amyloidosis: PYP, DPD, HMDP, Perugini Grading and Diagnostic Interpretation

Bone scintigraphy is central to the non-invasive diagnosis of transthyretin cardiac amyloidosis. This article explains PYP, DPD and HMDP imaging, Perugini grading, SPECT, the H/CL ratio, monoclonal protein testing and when biopsy is still required.

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Amyloidosis Diagnosis

Echocardiography in Cardiac Amyloidosis: Recognizing the Red Flags

Echocardiography is central to recognizing cardiac amyloidosis. Explore the key echo red flags, including increased ventricular wall thickness, restrictive filling, reduced tissue Doppler velocities, impaired global longitudinal strain, and relative apical sparing.

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Amyloidosis Diagnosis

How Is Cardiac Amyloidosis Diagnosed? A Step-by-Step Diagnostic Approach

Cardiac amyloidosis diagnosis requires a structured approach. Learn how ECG, echocardiography, CMR, monoclonal protein testing, bone scintigraphy, biopsy and genetic testing are used to distinguish ATTR from AL amyloidosis.

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Amyloidosis Treatment

TTR Stabilization in Cardiac Amyloidosis: How It Works & When It’s Used

Learn how TTR stabilizers such as tafamidis and acoramidis slow ATTR cardiac amyloidosis, how they work, what clinical trials show, and how stabilization differs from gene silencing.

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Amyloidosis Treatment

Gene Silencers in Cardiac Amyloidosis: How They Work & When They’re Used

Learn how gene silencers reduce transthyretin production in ATTR cardiac amyloidosis, how vutrisiran works, what clinical trials show, and how these therapies differ from TTR stabilizers.

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Amyloidosis Treatment

Pacemaker in Cardiac Amyloidosis: How It Works & When It’s Used

Learn how pacemakers are used in cardiac amyloidosis, when implantation may be needed, how the procedure works, and why pacing strategy and follow-up matter.

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Amyloidosis Treatment

ICD Implantation in Cardiac Amyloidosis: How It Works & When It’s Used

Learn how implantable cardioverter-defibrillators (ICDs) work in cardiac amyloidosis, when they may be considered, how implantation is performed, and why patient selection is essential.

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Amyloidosis Treatment

Device Therapy in Cardiac Amyloidosis: Pacemakers, ICDs and Cardiac Resynchronization Therapy

Learn how pacemakers, ICDs and cardiac resynchronization therapy (CRT) are used in cardiac amyloidosis, including their indications, potential benefits, limitations and the importance of individualized patient selection.

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Amyloidosis Treatment

Liver Transplantation in Amyloidosis: When Is It Considered?

Liver transplantation was historically an important disease-modifying treatment for hereditary ATTR amyloidosis. Learn which patients may still be considered today, how genotype and cardiac involvement affect eligibility, why disease can progress after transplantation, and how modern TTR-directed therapies have changed its role.

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Amyloidosis Treatment

Kidney Transplantation in Amyloidosis: Who Is a Canddidate?

Kidney transplantation can offer selected patients with amyloidosis-related kidney failure long-term dialysis independence. Learn how amyloid type, disease control, cardiac involvement and recurrence risk influence transplant eligibility and outcomes.

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Amyloidosis Treatment

Heart Transplantation in Cardiac Amyloidosis: Patient Selection, Eligibility and Outcomes

Heart transplantation can be an important treatment option for carefully selected patients with advanced cardiac amyloidosis. Learn how transplant teams assess eligibility, the differences between AL and ATTR amyloidosis, extracardiac disease, combined-organ transplantation and modern transplant outcomes.

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Amyloidosis Treatment

Organ Transplantation in Amyloidosis: When Is It Considered?

Organ transplantation can be an important treatment option for carefully selected patients with amyloidosis and advanced organ dysfunction. This article explains when heart, kidney, liver, or combined transplantation may be considered in AL, ATTR, and AA amyloidosis, and why disease control and multidisciplinary assessment are essential.

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Amyloidosis Treatment

Cardiac Amyloidosis Treatment: ATTR, AL and Heart Failure Management

Cardiac amyloidosis treatment depends on the amyloid type. This guide explains current ATTR and AL therapies, including TTR stabilizers, TTR silencers, plasma-cell-directed treatment, diuretics, anticoagulation and multidisciplinary heart failure care.

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Blog

Blog

Why Africa Needs Its Own Amyloidosis Research and Registries

Amyloidosis registries in Africa can improve diagnosis, research, and treatment. Discover why Africa needs its own amyloidosis data systems.

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Blog

Cardiac Amyloidosis in Africa: An Overlooked Cause of Heart Failure

Cardiac amyloidosis in Africa is an overlooked cause of heart failure. Learn key symptoms, diagnostic clues, and why early detection matters.

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Blog

Why Amyloidosis Is Often Missed in Africa and How Awareness Can Save Lives

Amyloidosis awareness in Africa is improving, but many cases are still missed. Learn why early recognition is critical for saving lives.

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Blog

Heart Failure but Different: Why Cardiac Amyloidosis Requires a Different Treatment Approach

Not all heart failure is the same. Learn why cardiac amyloidosis needs a different treatment approach and which drugs should be avoided.

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Blog

Cardiac Amyloidosis in Africa: Current Challenges and Opportunities

Cardiac amyloidosis in Africa remains under-recognized and under-researched. This article explores diagnostic barriers, genetic relevance, treatment access, workforce gaps, research priorities and opportunities to improve care across the continent.

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Cardiac Amyloidosis Mimics

Cardiac Amyloidosis vs Hypertrophic Cardiomyopathy: How to Tell Them Apart

Cardiac amyloidosis and hypertrophic cardiomyopathy can both cause ventricular wall thickening, diastolic dysfunction and abnormal myocardial strain. Learn how echocardiography, GLS, cardiac MRI, clinical red flags and diagnostic testing help distinguish these conditions.

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Cardiac Amyloidosis Mimics

Cardiac Amyloidosis vs Hypertensive Heart Disease: How to Tell Them Apart

Cardiac amyloidosis and hypertensive heart disease can both cause left ventricular hypertrophy, diastolic dysfunction and heart failure. Learn how echocardiography, global longitudinal strain (GLS), cardiac MRI, ECG findings and clinical red flags help distinguish these conditions.

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Cardiac Amyloidosis Mimics

Cardiac Amyloidosis vs Aortic Stenosis: How to Tell Them Apart

Cardiac amyloidosis and aortic stenosis can cause similar cardiac abnormalities and frequently coexist in older adults. Learn how echocardiography, global longitudinal strain (GLS), cardiac MRI and bone scintigraphy help identify ATTR cardiomyopathy in patients with aortic stenosis, including those undergoing TAVR.

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Cardiac Amyloidosis Mimics

Cardiac Amyloidosis vs Fabry Disease: How to Tell Them Apart

Cardiac amyloidosis and Fabry disease can both cause left ventricular wall thickening, abnormal myocardial strain and heart failure. Discover how cardiac MRI, native T1 mapping, extracellular volume (ECV), clinical red flags and disease-specific testing help distinguish these two conditions.

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Cardiac Amyloidosis Mimics

Cardiac Amyloidosis vs Constrictive Pericarditis: How to Tell Them Apart

Cardiac amyloidosis and constrictive pericarditis can cause similar symptoms of heart failure and restrictive filling. Learn how echocardiography, tissue Doppler, cardiac MRI, and invasive hemodynamics help distinguish these conditions and guide appropriate treatment.

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African Countries

Active engagement and collaboration across the continent

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Healthcare Partners

Clinicians, researchers, and institutions involved

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Education & Research Initiatives

Courses, webinars, studies, and collaborations

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Communities Reached

Patients and professionals impacted across Africa

STAY TUNED

News, Updates, and Insights from Amyloidosis Africa

Stay informed about the latest developments in amyloidosis awareness, medical education, research, and collaboration across Africa. This section highlights key initiatives, events, publications, and partnerships shaping the future of amyloidosis care on the continent.